Crystal structure of hsDHFR in complex with NADP+, DAP, and R-naproxen

Crystal structure of hsDHFR in complex with NADP+, DAP, and R-naproxen Descriptor: (2R)-2-(6-methoxynaphthalen-2-yl)propanoic acid, Dihydrofolate reductase, FOLIC ACID, ... Authors: Pedersen, L.C, London, R.E, Gabel, S.A, Krahn, J.M, DeRose, E.F. Deposit date: 2019-12-21 Release date: 2020-10-28 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.34 Å) Cite: The Structural Basis for Nonsteroidal Anti-Inflammatory Drug Inhibition of Human Dihydrofolate Reductase. J.Med.Chem., 63, 2020

人源二氢叶酸还原酶（hsDHFR）与烟酰胺腺嘌呤二核苷酸磷酸（NADP+）、二氨基庚二酸（DAP）以及R-萘普生形成复合物的晶体结构。描述信息：(2R)-2-(6-甲氧基萘-2-基)丙酸、二氢叶酸还原酶（Dihydrofolate reductase）、叶酸（FOLIC ACID）等。作者：Pedersen, L.C.、London, R.E.、Gabel, S.A.、Krahn, J.M.、DeRose, E.F.。入库日期：2019-12-21；发布日期：2020-10-28；最后修改日期：2023-10-11。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.34埃（Å）。引用文献：《人二氢叶酸还原酶被非甾体抗炎药抑制的结构基础》，《J.Med.Chem.》，第63卷，2020年。