Crystal structure of Penicillin Binding Protein 5 (PBP5) T485A variant with S466 insertion penicillin bound form from Enterococcus faecium

Crystal structure of Penicillin Binding Protein 5 (PBP5) T485A variant with S466 insertion penicillin bound form from Enterococcus faecium Descriptor: OPEN FORM - PENICILLIN G, Penicillin binding protein 5, SULFATE ION Authors: D'Andrea, E.D, Choy, M.S, Schoenle, M.V, Page, R, Peti, W. Deposit date: 2022-11-10 Release date: 2023-07-05 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.99 Å) Cite: The Molecular Basis for Resistance of E. faecium PBP5 to beta-lactam Antibiotics Nat Commun, 2023

来自屎肠球菌（Enterococcus faecium）的、携带S466插入突变的青霉素结合蛋白5（Penicillin Binding Protein 5, PBP5）T485A变体的青霉素结合状态晶体结构。描述项：开放构象——青霉素G、青霉素结合蛋白5、硫酸根离子。作者：D'Andrea, E.D、Choy, M.S、Schoenle, M.V、Page, R、Peti, W. 提交日期：2022-11-10；发布日期：2023-07-05；最后修改日期：2024-10-30。实验方法：X射线衍射（分辨率2.99 Å）。引用文献：《屎肠球菌PBP5对β-内酰胺类抗生素耐药性的分子基础》，《自然·通讯》（Nat Commun），2023年。