Identification of genetic cause of a T- and B-cell deficiency in mice. Identification of genetic cause of a T- and B-cell deficiency in mice

Here we describe a novel, spontaneous, 4035 basepairs long deletion in the DNA cross-link repair 1C (Dclre1c)-locus in C57BL/6-mice, which leads to loss of exons 10 and 11 of the gene encoding for Artemis, a protein involved into V(D)J-recombination of antigen receptors of T and B cells.