Activation of ERRγ enhances mitochondrial and sarcomere maturation in human induced pluripotent stem cell-derived cardiomyocytes
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
下载链接：
http://data.iscr.ac.cn/Article?id=f751f314884544d3f5a1ddef964524d8
下载链接
链接失效反馈官方服务：
资源简介：
We identified two cardiac maturation stimulators from 9,048 compounds using Troponin I1 (TNNI1) and Troponin I3 (TNNI3) double reporter hiPSC-derived CMs. An estrogen-related receptor gamma (ERRγ)-specific agonist increased the size of hiPSC-CMs and their mitochondrial content and enhanced their mitochondrial function. In addition, combination of this agonist with an inhibitor of S-phase kinase-associated protein 2 (SKP2) increased the TNNI3 expression more highly than previous methods and enhanced cardiac maturation-related gene expression profiles.
提供机构：
Kyoto University
创建时间：
2022-02-20
