miRNAs expression in murine liver during Schistosoma japonicum infection

It is well recognized that parasitic helminth infections, which afflict more than one billion people globally, correlate with a decreased prevalence of metabolic diseases, including obesity and type 2 diabetes, but the molecular mechanisms involved remain to be determined. Using microarrays, we quantified the temporal gene expression profiles in the liver of Schistosoma japonicum-infected C57BL/6 mice at 9 weeks post infection with that from uninfected mice as controls.  More than 150 miRNAs were differentially expressed in the liver during S. japonicum infection, and miRNA-mRNA network would provide new evidence for the negtive correlation between S. japonicum infection and metabolism. miRNAs expression in the livers of C57BL/6 mice was measured at 9 weeks after S. japonicum infection.  5 liver samples combined from uninfected mice or S. japonicum-infected mice.