Crystal Structure of Human APRT-Tyr105Phe variant in complex with Adenine, PRPP and Mg2+, 14 days post crystallization (with AMP and PPi products partially generated)

Crystal Structure of Human APRT-Tyr105Phe variant in complex with Adenine, PRPP and Mg2+, 14 days post crystallization (with AMP and PPi products partially generated) Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, ADENOSINE MONOPHOSPHATE, Adenine phosphoribosyltransferase, ... Authors: Nioche, P, Huyet, J, Ozeir, M. Deposit date: 2017-12-21 Release date: 2018-08-15 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Structural Insights into the Forward and Reverse Enzymatic Reactions in Human Adenine Phosphoribosyltransferase. Cell Chem Biol, 25, 2018

人源腺嘌呤磷酸核糖转移酶（Adenine phosphoribosyltransferase, APRT）Tyr105Phe突变体与腺嘌呤、5-磷酸核糖-1-焦磷酸（PRPP）及Mg²+结合的晶体结构，结晶14天后（体系中已部分生成一磷酸腺苷（AMP）与焦磷酸（PPi）产物）。描述项：1-O-焦磷酸酰基-5-O-磷酸酰基-α-D-呋喃核糖、一磷酸腺苷、腺嘌呤磷酸核糖转移酶……作者：Nioche, P、Huyet, J、Ozeir, M。提交日期：2017-12-21；发布日期：2018-08-15；最后修改日期：2024-01-17。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.55 Å。引用文献：《人源腺嘌呤磷酸核糖转移酶正反催化反应的结构解析》，发表于《细胞化学与生物学（Cell Chem Biol）》2018年第25卷。