Breast Cancer - immune clusters - RNA-seq

We use expression data from breast cancer tumors to define immune clusters in breast cancer. Immune clusters have gradual levels of immune infiltration. In the intermediate immune infiltration cluster, we found a worse prognosis which is independent of known clinicopathological features. We also found the immune clusters associated with treatment response. Further we use gene expression data and deconvolution algorithms to dissect the immune contexture of the clusters. RNA-seq gene expression profiling of breast tumors ****************************************************************** Raw data are not publicly available due to patient privacy concerns. Raw data have been submitted for controlled access at EGA: EGAS00001003631. ******************************************************************