Relative density of nonsynonymous variants (rdnsv).

Candidate genes for the nervous system (NSG) and the immune system (ISG) are defined by tissue specific expression or keyword search and further compared with a set of randomly sampled genes (RSG). A) Overall rdnsv estimates for a diploid genome and 200 exome sequences, which reflect the density of nonsynonymous variants on a mixture of SNVs that range from rare to common in their population frequency. B) SNVs from the 200 exome dataset are additionally stratified by their derived allele frequency and a regression model is fitted to the values of rdnsv. The predicted value for the allele frequency of 0 is referred to as rdnsv0, whereas the predicted value for the allele frequency of 1 is referred to as rdnsv1. The interval in brackets shows the 2.5% and 97.5% quantiles from 10.000 random draws of genes.