p53-mediated cellular response to DNA damage in cells with replicative hepatitis B virus.
收藏PubMed Central1995-02-28 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC42515/
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资源简介：
Wild-type p53 acts as a tumor suppressor gene by protecting cells from deleterious effects of genotoxic agents through the induction of a G1/S arrest or apoptosis as a response to DNA damage. Transforming proteins of several oncogenic DNA viruses inactivate tumor suppressor activity of p53 by blocking this cellular response. To test whether hepatitis B virus displays a similar effect, we studied the p53-mediated cellular response to DNA damage in 2215 hepatoma cells with replicative hepatitis B virus. We demonstrate that hepatitis B virus replication does not interfere with known cellular functions of p53 protein. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1995-02-28
