File S1 - Simulating an Infection Growth Model in Certain Healthy Metabolic Pathways of Homo sapiens for Highlighting Their Role in Type I Diabetes mellitus Using Fire-Spread Strategy, Feedbacks and Sensitivities

Supporting information. Figure S1. Spread of infection in glutamate metabolism with infection start site as ‘3’. Figure S2. Spread of infection in glutamate metabolism with infection start site as ‘4’. Figure S3. Combat process in glutamate metabolism with infection start site as ‘3’. Figure S4. Combat process in glutamate metabolism in H. sapiens with infection start site as ‘4’. Figure S5. Plot representing distribution of critical values in all metabolic pathways in H. sapiens. Figure S6. -alanine metabolism; Infection start site = -alanine. Figure S7. -alanine metabolism; Infection start site = L-aspartate. Figure S8. -alanine metabolism; Combat analysis for infection start site = -alanine. Figure S9. -alanine metabolism; Combat analysis for infection start site = L-aspartate. Figure S10. Taurine and hypotaurine metabolism; Infection start site = 3-sulfino-L-alanine. Figure S11. Taurine and hypotaurine metabolism; Infection start site = taurine. Figure S12. Taurine and hypotaurine metabolism; Combat analysis for infection start site = 3-sulfino-L-alanine. Figure S13. Taurine and hypotaurine metabolism; Combat analysis for infection start site = taurine. Figure S14. Taurine and hypotaurine metabolism; Combat analysis for infection start site = L-cysteate. Figure S15. Taurine and hypotaurine metabolism; Infection start site = L-cysteate. Figure S16. Taurine and hypotaurine metabolism; Infection start site = hypotaurine. Figure S17. Butanoate metabolism; Infection start site = 4-aminobutanoate. Figure S18. Butanoate metabolism; Infection start site = L-glutamate. Figure S19. Butanoate metabolism; Combat analysis for infection start site = 4-aminobutanoate. Figure S20. Butanoate metabolism; Combat analysis for infection start site = L-glutamate. Figure S21. Feedback analysis. Figure S22. Global sensitivity analysis of -alanine metabolism. Figure S23. Global sensitivity analysis of taurine-hypotaurine metabolism. Figure S24. Global sensitivity analysis of butanoate metabolism. Table S1. Target function, non-constant concentration of species, variable, initial concentration in glutamate metabolism. Table S2. Target function, concentration fluxes of reactions, variable, initial concentration in -alanine metabolism. Table S3. Target function, concentration fluxes of reactions, variable, initial concentration in taurine and hypotaurine metabolism. Table S4. Target function, concentration fluxes of reactions, variable, initial concentration in butanoate metabolism. Table S5. Identification of infected, cured and un-cured metabolites in the four metabolic pathways. Table S6. Critical value analysis in the four metabolic pathways. Table S7. Perturbations in -alanine metabolism. Table S8. Perturbations in taurine and hypotaurine metabolism. Table S9. Perturbations in butanoate metabolism. Table S10. Perturbations in glutamate metabolism. (DOC)