Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor N-(3,5-dichlorobenzyl)-N'-(1H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine (Chem 1575)

Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor N-(3,5-dichlorobenzyl)-N'-(1H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine (Chem 1575) Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, METHIONINE, ... Authors: Koh, C.-Y, Hol, W.G.J. Deposit date: 2015-05-14 Release date: 2016-05-04 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.7 Å) Cite: 5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors. Acs Infect Dis., 2, 2016

本数据集为布氏锥虫（Trypanosoma brucei）甲硫氨酰-tRNA合成酶（methionyl-tRNA synthetase）与抑制剂N-(3,5-二氯苄基)-N'-(1H-咪唑并[4,5-b]吡啶-2-基)丙烷-1,3-二胺（Chem 1575）形成的复合物。组分：二甲基亚砜、甘油、甲硫氨酸…… 作者：Koh, C.-Y、Hol, W.G.J. 沉积日期：2015-05-14 发布日期：2016-05-04 最后修改日期：2024-11-06 解析方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.7埃（Å）。引用文献：《5-氟咪唑并[4,5-b]吡啶是可赋予强效锥虫甲硫氨酰-tRNA合成酶抑制剂生物利用度的优势片段》，发表于《Acs Infect Dis.》2016年第2卷。