Transcriptional profiling of kidneys from ADTKD-UMOD mouse model. Mus musculus

To gain insight into autosomal dominant tubulointerstitial kidney disease (ADTKD)-uromodulin (UMOD) pathophysiology, we carried out transcriptional profiling of kidneys from 1- and 2-month-old TgUmodC147W mice, a transgenic model that recapitulates the main features of the disease, and TgUmodwt mice, a matched transgenic control of Umod overexpression. These time points correspond to presymptomatic stages that precede renal dysfunction in TgUmodC147W mice. Overall design: Total RNA obtained from kidneys of mice at different ages carrying either wild type or mutant Umod transgene.