Afucosylation of Anti-Dengue IgG is Associated with Enhanced Susceptibility to Dengue Virus Infection Post-Vaccination

We examined IgG characteristics before and after DENV vaccination (Dengvaxia) in individuals with a history of prior DENV exposure, comparing those who developed post-vaccination infections to those who remained infection-free. Elevated anti-DENV afucosylation, present before or after vaccination, was associated with increased likelihood of infection after vaccination.