DDR1, 2-[4-bromo-2-oxo-1'-(1H-pyrazolo[4,3-b]pyridine-5-carbonyl)spiro[indole-3,4'-piperidine]-1-yl]-N-(2,2,2-trifluoroethyl)acetamide, 1.291A, P212121, Rfree=17.4%

DDR1, 2-[4-bromo-2-oxo-1'-(1H-pyrazolo[4,3-b]pyridine-5-carbonyl)spiro[indole-3,4'-piperidine]-1-yl]-N-(2,2,2-trifluoroethyl)acetamide, 1.291A, P212121, Rfree=17.4% Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[4-bromanyl-2-oxidanylidene-1'-(1~{H}-pyrazolo[4,3-b]pyridin-5-ylcarbonyl)spiro[indole-3,4'-piperidine]-1-yl]-~{N}-[2,2,2-tris(fluoranyl)ethyl]ethanamide, CHLORIDE ION, ... Authors: Stihle, M, Richter, H, Benz, J, Kuhn, B, Rudolph, M.G. Deposit date: 2018-01-03 Release date: 2018-11-28 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.291 Å) Cite: DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome. Acs Chem.Biol., 14, 2019

DDR1，化合物：2-[4-溴-2-氧代-1'-(1H-吡唑并[4,3-b]吡啶-5-甲酰基)螺[吲哚-3,4'-哌啶]-1-基]-N-(2,2,2-三氟乙基)乙酰胺；衍射波长1.291 Å，空间群P212121，自由R因子（Rfree）=17.4%。描述项：2-(N-吗啉代)乙磺酸（2-(N-MORPHOLINO)-ETHANESULFONIC ACID）、2-[4-溴基-2-氧亚基-1'-(1~H-吡唑并[4,3-b]吡啶-5-羰基)螺[吲哚-3,4'-哌啶]-1-基]-~N-[2,2,2-三氟乙基]乙酰胺、氯离子（CHLORIDE ION）等。作者：Stihle M、Richter H、Benz J、Kuhn B、Rudolph M.G.；沉积日期：2018-01-03；发布日期：2018-11-28；最后修改日期：2024-05-01；实验方法：X射线衍射（X-RAY DIFFRACTION，衍射波长1.291 Å）；引用文献：《DNA编码文库衍生的DDR1抑制剂在遗传性Alport综合征小鼠模型中预防纤维化与肾功能丧失》，发表于《Acs Chem.Biol.》，第14卷，2019年。