Dipeptidase-1 knockout mice develop invasive tumors with features of microsatellite unstable colorectal cancer

The goal of this study was to employ a single cell RNA sequencing approach to determine cell population differences between wildtype and DPEP1 KO mice that were induced to form distal colonic tumors by an AOM/DSS regimen. This study represents the first scRNA-seq assessment of tumors formed in DPEP1 KO mice Overall design: Following an AOM/DSS regimen of treatment for mice and waiting for 105 days, resulting tumors were removed and analyzed by scRNA-seq