DataSheet1_Studies toward synthesis of the core skeleton of spiroaspertrione A.PDF

Bioassay-guided isolation of spiroaspertrione A from cultures of Aspergillus sp. TJ23 in 2017 demonstrated potent resensitization of oxacillin against methicillin-resistant Staphylococcus aureus by lowering the oxacillin minimal inhibitory concentration up to 32-fold. To construct this unique spiro[bicyclo[3.2.2]nonane-2,1′-cyclohexane] system, a protocol for ceric ammonium nitrate-induced intramolecular cross-coupling of silyl enolate is disclosed.

2017年，从Aspergillus sp. TJ23的培养物中通过生物活性指导分离出spiroaspertrione A，该研究揭示了通过降低oxacillin的最小抑菌浓度至原浓度的1/32，能够显著提高对甲氧西林耐药金黄色葡萄球菌的复敏效果。为构建独特的spiro[bicyclo[3.2.2]nonane-2,1′-cyclohexane]系统，本项研究公开了一种基于硝酸铵盐诱导的硅基烯醇内分子交叉偶联的实验方法。