Nuclear tRNA sequestering slows aging by a mechanism similar to dietary restriction

ChEBI2015-02-03 更新2026-07-21 收录

衰老分子机制

tRNA细胞定位

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-37241 数据链接链接失效反馈

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Nuclear tRNA sequestering slows aging by a mechanism similar to dietary restriction

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2015-02-03

Summary of DAF-16::GFP Nuclear Localization Data.

衰老分子机制

胰岛素信号通路

Animals were scored for presence of nuclear puncta after treatment with DMSO, daf-2(RNAi), FLA or following a 2 hour heat-shock incubation at 37°C. A Student's T-Test was used to determine statistical

NIAID Data Ecosystem70

Genes up-regulated in daf-10(m79) mutants versus wild-type animals.

线虫基因表达谱

衰老分子机制

A = up-regulated in a daf-16-dependent fashion in daf-2 mutants, Murphy et al., 2003 [31].B = up-regulated in a daf-16-dependent fashion in daf-2 mutants, McElwee et al., 2004 [35].C = up-regulated in

Figshare2015-12-02 更新40

Comparison of gene expression in the long-lived hsb-1 mutant and hsf-1 overexpression C. elegans strains

衰老分子机制

转录组差异分析

Purpose: We used RNA-Seq to compare the gene expression profiles in two long-lived C. elegans strains: (1) animals with a loss-of-function mutation in the hsb-1 gene, and (2) animals overexpressing hs

NIAID Data Ecosystem30

Impact of cognitive performance and normal aging on transcriptomic changes in the prefrontal cortex of rats. Impact of cognitive performance and normal aging on transcriptomic changes in the prefrontal cortex of rats

衰老分子机制

转录组学分析

We investigated how cognitive stimulation impacts gene expression in the prefrontal cortex (PFC), a brain region known to regulate higher cognitive functions including the control of attention, in you

NIAID Data Ecosystem60

Young Human Plasma Rejuvenates Senescent Vascular Endothelial Cell through Multiple Pathways

血管内皮细胞

衰老分子机制

A mouse parabiotic model supports the existence of transferable factor(s) in blood that rescue(s) age-related degenerative phenotypes, however, whether it prevents endothelial cell senescence linked t

NIAID Data Ecosystem40

Nuclear tRNA sequestering slows aging by a mechanism similar to dietary restriction

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