Prenatal Stress (PRS) exposure strengthened depressive- and anxiety-like behavior of Submissive (Sub) offspring

Sub PRS mice spent less time drinking sweetened milk when placed in the DSR test against their naïve counterparts (A), while Dom PRS mice display stable competition for food, in competition with Dom naïve (B). Sub PRS mice exhibited heightened immobility in the FST (C), relative to both Sub naïve and Dom PRS mice, without altered locomotion in the Open Field (D). In the EPM, open time: total time indexes of Sub PRS mice were significantly lower than those of Dom PRS (E), without changes in the proportion of mice’s entries to open arms (F).

在DSR测试中，亚型PRS小鼠相较于其天真型对照小鼠，花费在饮用甜味牛奶上的时间减少（A），而优势型PRS小鼠在与天真型优势型小鼠的竞争中表现出稳定的食物竞争态势（B）。亚型PRS小鼠在FST测试中表现出相对于亚型天真型和优势型PRS小鼠的显著增加的不动性（C），而在开放场测试（D）中，其运动行为未发生改变。在EPM测试中，开放时间：亚型PRS小鼠的总时间指数显著低于优势型PRS小鼠（E），而小鼠进入开放臂的比例未发生变化（F）。