Crebbp loss drives small cell lung cancer and increases sensitivity to HDAC inhibition [SCLC]. Crebbp loss drives small cell lung cancer and increases sensitivity to HDAC inhibition [SCLC]

This study assessed tumor suppressor roles of CREBBP in SCLC and other neuroendocrine tumors. Genetically engineered mouse models were used to determine the tumor suppressor role of Crebbp in SCLC and other neuroendocrine tumors. Overall design: Identification of differentially expressed genes regulated by Crebbp using primary SCLC tumors derived from genetically engineered mouse model.