3D cyto- and receptor architectonic map of macaque orbitofrontal area 13l (v1.0)

A multimodal analysis of the macaque prefrontal cortex was carried out to create a 3D atlas integrating and reconciling discrepancies between previously published maps. This project involved a quantitative and statistically testable approach to the analysis of cytoarchitecture in the macaque monkey frontal lobe, in combination with an in vitro quantitative receptor autoradiographic analysis of the regional and laminar distribution patterns of 14 different neurotransmitter receptors. The borders of the identified areas were traced onto a reference macaque monkey brain in stereotaxic space. We provide here for the first time a map of orbitofrontal area 13l of the macaque monkey brain integrating cyto- and receptor architectonic features in stereotaxic space. It constitutes a valuable resource for the analysis of functional experiments with non-human primates and provides crucial data for modeling approaches with realistic synaptic dynamics.本研究针对猕猴前额叶皮层（macaque prefrontal cortex）开展多模态分析，以期构建整合既往已发表图谱并调和其间分歧的三维图谱（3D atlas）。本项目采用定量且可经统计学检验的方法分析猕猴额叶的细胞构筑学（cytoarchitecture）特征，并结合体外（in vitro）定量受体放射自显影分析（receptor autoradiographic analysis），解析14种不同神经递质受体（neurotransmitter receptors）的脑区与层状分布模式。研究团队将所识别脑区的边界描记至立体定位空间（stereotaxic space）中的猕猴标准脑模板上。本研究首次构建了猕猴脑眶额叶13l区（orbitofrontal area 13l）的图谱，该图谱整合了立体定位空间内的细胞构筑与受体构筑特征。该图谱可为非人类灵长类（non-human primates）的功能实验分析提供宝贵的研究资源，同时为基于真实突触动力学（synaptic dynamics）的建模研究提供关键数据。