Therapeutic Targeting of EZH2 and BET BRD4 in Pediatric Rhabdoid Tumor

We proved that histone H3K27me3 and H3K27ac were elevated in AT/RT cells and distributed in distinct chromatin regions to regulate specific gene expression and to promote AT/RT growth. Targeting EZH2 and BRD4 activity is therefore a potential combination therapy for AT/RT. DNA methylation array was used to determine the molecular profile of AT/RT cell lines. Genome Studio v2011.1 was used for data processing.