Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SOSIP.664 (conformation 1)

Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SOSIP.664 (conformation 1) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... Authors: Changela, A, Gorman, J, Kwong, P.D. Deposit date: 2023-02-22 Release date: 2023-04-19 Last modified: 2024-11-20 Method: ELECTRON MICROSCOPY (4.66 Å) Cite: Diverse Murine Vaccinations Reveal Distinct Antibody Classes to Target Fusion Peptide and Variation in Peptide Length to Improve HIV Neutralization. J.Virol., 97, 2023

与HIV-1包膜蛋白（HIV-1 Env）BG505 DS-SOSIP.664（构象1）形成复合物的vFP49.02抗原结合片段（Fab）的冷冻电镜（Cryo-EM）结构。结构描述符：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose）、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose）、包膜糖蛋白gp120（Envelope glycoprotein gp120）……。作者：Changela, A、Gorman, J、Kwong, P.D.。沉积日期：2023-02-22；发布日期：2023-04-19；最后修改日期：2024-11-20。实验方法：电子显微镜法（分辨率4.66 Å）。引用文献：《不同小鼠免疫策略揭示靶向融合肽的不同抗体类别及肽长度变异以增强HIV中和活性》，《病毒学杂志（J.Virol.）》，第97卷，2023年。