RNA-seq analysis of E11.5 and E12.5 Mboat7 KO cortices

To investigate whether Mboat7 KO mice showed any abnormality before E11.5, we evaluated the global gene expression patterns in the cortices of Mboat7 heterozygous mice and KO mice at E11.5 using RNA-sequencing. No significant differences in gene expression were observed, suggesting that Mboat7 KO mice develop normally until E11.5. Even at E12.5 when the phenotype starts to become apparent, little difference in gene expression were observed in Mboat7 KO mice. RNA-seq profiling of E11.5 and E12.5 cortices obtained from Mboat7+/- and Mboat7-/- mice.