Processed genomic data supporting manuscript "A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction"

This repository contains a collection of supporting data to reproduce the Figures with the genomic analyses of the manuscript "A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction". The repository contains a processed version of the raw data available through the GEO identifier GSE247096 and the ArrayExpress E-MTAB-13890. Description of the different tables:

rnadiff_dwiz2_t0.tsv: Differential gene expression analysis (dWIZ-2 vs DMSO) in erythroblasts at differentiation day 0.

rnadiff_wizko_t7.tsv: Differential gene expression analysis (WIZ-gRNA vs nt-gRNA) in erythroblasts at differentiation day 0.

rnadiff_dwiz2_t7.tsv: Differential gene expression analysis (dWIZ-2 vs DMSO) in erythroblasts at differentiation day 7.

rnadiff_unc_t7.tsv: Differential gene expression analysis (UNC0642 vs DMSO) in erythroblasts at differentiation day 7.

wizpeaks.bed: File in bed format with the coordinates of the union of WIZ peaks in erythroblasts at differentiation days 2 and 4.

ctcfpeaks.bed: File in bed format with the coordinates of the CTCF peaks in erythroblasts at differentiation day 4. 

h3k9acpeaks.bed: File in bed format with the coordinates of the H3K9ac peaks in erythroblasts at differentiation day 4. 

compartment.bed: Eigenvector decomposition of Hi-C matrices of differentiating erythroblasts (used to define chromatin compartments). Raw Hi-C data was generated by Huang et al. and is available in the GEO repository GSE102201. 

dwiz2_ms_quantifications.txt: Table with MS quantification of H3 peptide modifications.

wizdiff_dwiz2.tsv: Peak-level differential analysis (dWIZ-2 vs DMSO) of WIZ CUT&RUN in erythroblasts at differentiation day 4.

k9acdiff_dwiz2_t4.tsv: Peak-level differential analysis (dWIZ-2 vs DMSO) of H3K9ac CUT&RUN in erythroblasts at differentiation day 4.

k9me2diff_dwiz2_t4.tsv: 10Kb genomic bin differential analyses (dWIZ-2 vs DMSO) of H3K9ac CUT&RUN in erythroblasts at differentiation day 4. 

k9me2diff_all_t4.tsv: 10Kb genomic bin differential analyses (dWIZ-2 vs DMSO, dWIZ-1 vs DMSO, WIZ-gRNA vs ntc-gRNA and UNC0642 vs control) of H3K9ac CUT&RUN in erythroblasts at differentiation day 4.

figureS11AData_public.tsv: Table with collection of coverage tracks of public CUT&RUN and ChIP-seq profiles at the Beta-globin locus. Raw data from this collection originates from the GEO entries GSE43625, GSE52924, GSE150530 and GSE104676.