FphE, Staphylococcus aureus fluorophosphonate-binding serine hydrolases E, boronic acid-based compound Z27 bound

FphE, Staphylococcus aureus fluorophosphonate-binding serine hydrolases E, boronic acid-based compound Z27 bound Descriptor: 1-benzothiophen-3-ylboronic acid, CALCIUM ION, Fluorophosphonate-binding serine hydrolase E Authors: Fellner, M. Deposit date: 2023-10-05 Release date: 2024-10-16 Last modified: 2025-06-25 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Identification of covalent inhibitors of Staphylococcus aureus serine hydrolases important for virulence and biofilm formation. Nat Commun, 16, 2025

FphE，即金黄色葡萄球菌氟膦酸结合丝氨酸水解酶E（Staphylococcus aureus fluorophosphonate-binding serine hydrolases E），结合了硼酸类化合物Z27（配体为1-苯并噻吩-3-硼酸（1-benzothiophen-3-ylboronic acid））与钙离子（CALCIUM ION）。作者：Fellner, M.；沉积日期：2023-10-05；发布日期：2024-10-16；最后修改日期：2025-06-25；实验方法：X射线衍射（1.65 Å）；引用文献：《鉴定与金黄色葡萄球菌毒力及生物膜形成相关的丝氨酸水解酶共价抑制剂》，发表于Nat Commun，16卷，2025年。