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Target miRNAs of MLL-AF9 as revealed by RNAi

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE70525
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In this study the function of MLL-AF9 was investigated by efficient and specific knockdown via siRNAs in the AML M5 cell line THP1 which harbors the corresponding t(9;11) translocation. MiRNA expression profile analyses revealed 21 differentially expressed miRNAs. 4 samples were analyzed, each corresponding to a pool of five replicate experiments. MLL-AF9 knockdown treatments are represented by 2 samples employing two distinct siRNAs, each targeting MLL-AF9 breakpoint of THP1 cells. Control treatments are represented by 2 samples employing two distinct non-targeting control siRNAs.
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2016-01-16
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