Epigenetic profiling in 4 cohorts of pancreatic cancer patients revealed reduced expression of the chromatin factor inhibitor of growth family member 3 (ING3). Furthermore, using mass spectrometry ana
Additional file 5. Loops identified by in situ Hi-C. (A) Loops in three cell lines. (B) Genes looped to Capan-1 specific enhancers, compared with PANC-1. (C) GO enrichment analysis of genes looped to
Tissue-specific methylation patterns suggest a role for CpG island methylation in differentiation and cell-type-specific gene regulation. We have profiled CpG island methylation in different cells of
Abnormal differentiation contributes to the spectrum of aberrant properties of tumor cells. Differentiation of both normal and tumor cells is controlled by regulatory networks enforced by transcriptio
