Feasibility of quantifying arterial cerebral blood volume using multiphase alternate ascending/descending directional navigation (ALADDIN)

In this study, we evaluated the feasibility of a new 2D inter-slice bSSFP-based arterial spin labeling (ASL) technique termed, alternate ascending/descending directional navigation (ALADDIN), to quantify aCBV using multiphase acquisition in six healthy subjects. As a result of fitting to the proposed model, aCBV values in gray matter (1.4 – 2.3 mL/100 mL) were in good agreement with those from literature.