Prescribing behavior and decision-making in hospital practice: Proton pump inhibitor use as a case study from Japan

Background
While inappropriate proton pump inhibitors PPI use has been extensively documented in Western countries, prescribing behavior and its underlying decision-making patterns are poorly characterized in Japanese hospital settings. We aimed to examine the prescribing behavior of PPIs in a Japanese general hospital and to identify clinical and pharmacological factors associated with prescriptions lacking clear clinical justification.
Methods
This retrospective observational study involved adult inpatients who were prescribed oral PPIs between December 2017 and March 2018. Prescriptions were assessed for justification based on approved indications and commonly accepted off-label use. Patients were classified according to the presence or absence of clear prescribing justification. Multivariable logistic regression analysis was performed to identify factors associated with prescribing behavior lacking justification.
Results
Among 334 patients, 131 (39%) received PPIs without clear clin..., , , # Prescribing behavior and decision-making in hospital practice: Proton pump inhibitor use as a case study from Japan

[https://doi.org/10.5061/dryad.q2bvq83t4](https://doi.org/10.5061/dryad.q2bvq83t4)

Author(s)

Naoto Nakagawa, Phar.D., Ph.D.
School of Pharmaceutical Sciences, Ohu University, Koriyama, Fukushima, Japan
31-1 Misumido, Tomita-machi, Koriyama, Fukushima 963-8611, Japan
Email: [[e-mail]](mailto:[e-mail])

Keita Odanaka, Ph.D.
School of Pharmaceutical Sciences, Ohu University, Koriyama, Fukushima, Japan
31-1 Misumido, Tomita-machi, Koriyama, Fukushima 963-8611, Japan
Email: [[e-mail]](mailto:[e-mail])

Yoshitaka Okubo, BS, RPh.
Department of Pharmacy, Sendai Tokushukai Hospital, Sendai, Miyagi, Japan
9-8 Takadamacho, Izumi-ku, Sendai, Miyagi 981-3116, Japan
Email: [[e-mail]](mailto:[e-mail])

Tsutomu Ogata, BS, RPh

Department of Pharmacy, Sendai Tokushukai Hospita...,