Data from: Naturally acquired antibody responses to more than 300 Plasmodium vivax proteins in three geographic regions

Plasmodium vivax remains an important cause of malaria in South America
and the Asia-Pacific. Naturally acquired antibody responses against
multiple P. vivax proteins have been described in numerous countries,
however, direct comparison of these responses has been difficult with
different methodologies employed. We measured antibody responses against
307 P. vivax proteins at the time of P. vivax infection, and at 2–3 later
time-points in three countries. We observed that seropositivity rates at
the time of infection were highest in Thailand, followed by Brazil then
PNG, reflecting the level of antigenic input. The majority of
sero-reactive antigens in all sites induced short-lived antibody responses
with estimated half-lives of less than 6 months, although there was a
trend towards longer-lived responses in PNG children. Despite these
differences, IgG seropositivity rates, magnitude and longevity were highly
and significantly rank-correlated between the different regions,
suggesting such features are reflective of the individual protein.