Danio sp. Raw sequence reads. Danio sp.

Our study showed that compared to control, cobll1a-/- zebrafish embryos exhibited impaired development of digestive organs, including the liver, intestine, and pancreas at 4 dpf. Transcriptome sequencing and bioinformatics analysis results showed that in cobll1a knocked out, the expression of the genes in RA signaling pathway was affected, and the expression levels of lipid metabolisation-related genes fasn, scd, elovl2, elovl6, dgat1a, srebf1 and srebf2 were significantly changed (P<0.01), lipid synthesis was increased, and lipid metabolism was decreased. The expression of apolipoproteins apoa1a, apoa1b, apoa2, apoa4a, apoa4b, and apoea genes was down-regulated.