Crystal Structure of a cycloamide-urethane-derived novel inhibitor bound to human brain memapsin 2 (beta-secretase).

Crystal Structure of a cycloamide-urethane-derived novel inhibitor bound to human brain memapsin 2 (beta-secretase). Descriptor: Beta-secretase 1, N-[(4S,5S,7R)-8-({(S)-1-[(BENZYLAMINO)OXOMETHYL]-2-METHYLPROPYL}AMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXO-OCT-4-YL]-(4S,7S)-4 -ISOPROPYL-2,5,9-TRIOXO-1-OXA-3,6,10-TRIAZACYCLOHEXADECANE-7-CARBOXAMIDE Authors: Ghosh, A, Devasamudram, T, Hong, L, DeZutter, C, Xu, X, Weerasena, V, Koelsch, G, Bilcer, G, Tang, J. Deposit date: 2004-10-18 Release date: 2004-12-21 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase). Bioorg.Med.Chem.Lett., 15, 2005

结合于人脑memapsin 2（β-分泌酶，beta-secretase）的环酰胺-氨基甲酸酯类新型抑制剂的晶体结构。描述符：β-分泌酶1，N-[(4S,5S,7R)-8-({(S)-1-[(苄基氨基)氧代甲基]-2-甲基丙基}氨基)-5-羟基-2,7-二甲基-8-氧代辛-4-基]-(4S,7S)-4-异丙基-2,5,9-三氧代-1-氧杂-3,6,10-三氮杂环十六烷-7-甲酰胺。作者：Ghosh A、Devasamudram T、Hong L、DeZutter C、Xu X、Weerasena V、Koelsch G、Bilcer G、Tang J。存储日期：2004-10-18；发布日期：2004-12-21；最后修改日期：2024-11-13。实验方法：X射线衍射（2.8 Å）。引用文献：《基于结构设计的人脑memapsin 2（β-分泌酶）环酰胺-氨基甲酸酯类新型抑制剂》，Bioorg.Med.Chem.Lett.，15卷，2005年。