Fitness of 48 TDH3 promoter alleles in YPD

Quantifying the effect of changing TDH3 expression level and expression noise on fitness. These competitive fitness data are associated with the expression data collected in experiment FR-FCM-ZY8Y for the same TDH3 promoter alleles.
Conclusion:
The relationship between TDH3 expression level and fitness is not linear, since fitness is maximized at intermediate levels of expression. An increase in expression noise is beneficial for cell proliferation when the expression level is far from the optimum, but it is detrimental when the expression level is near the optimum.