Intestinal flora dysbiosis contributes to PND in aged mice

Postoperative intestinal flora dysbiosis is closely related to the occurrence of PND. We first examined the changes of intestinal flora and PND in mice after intramedullary fixation of tibial fractures, and then observed the changes of PND after regulating postoperative intestinal flora with probiotics, and explored the mechanism of PND induced by postoperative intestinal flora