Understanding the singular conformational landscape of the Tn antigens: Sulfur-for- oxygen substitution in the glycosidic linkage provides new insights into molecular recognition by an antibody
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Understanding the singular conformational landscape of the Tn antigens: Sulfur-for- oxygen substitution in the glycosidic linkage provides new insights into molecular recognition by an antibody Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-alpha-D-galactopyranose, APD(CG6)RP(NH2) peptide, ... Authors: Companon, I, Martinez-Saez, N, Castro-Lopez, J, Jimenez-Barbero, J, Bernardes, G.J.L, Busto, J.H, Avenoza, A, Jimenez-Oses, G, Hurtado-Guerrero, R, Peregrina, J.M, Corzana, F. Deposit date: 2017-02-20 Release date: 2018-06-27 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage. J.Am.Chem.Soc., 141, 2019
解析Tn抗原（Tn antigens）独特的构象空间：糖苷键处的硫代氧取代为抗体的分子识别机制提供全新见解
表征组分：1,2-乙二醇、2-乙酰氨基-2-脱氧-α-D-吡喃半乳糖、APD(CG6)RP(NH2) 肽……
作者：Companon, I、Martínez-Saez, N、Castro-Lopez, J、Jimenez-Barbero, J、Bernardes, G.J.L、Busto, J.H、Avenoza, A、Jimenez-Oses, G、Hurtado-Guerrero, R、Peregrina, J.M、Corzana, F.
提交日期：2017-02-20
发布日期：2018-06-27
最后修改日期：2024-01-17
实验方法：X射线衍射（分辨率1.7 Å）
引用文献：《基于结构设计强效肿瘤相关抗原：通过糖苷键处单原子O/S或O/Se取代调控肽段呈递》，《美国化学会志》（J. Am. Chem. Soc.），141卷，2019年
创建时间：
2017-02-20
