Dog beta3 adrenergic receptor bound to mirabegron in complex with a miniGs heterotrimer

Dog beta3 adrenergic receptor bound to mirabegron in complex with a miniGs heterotrimer Descriptor: 2-(2-azanyl-1,3-thiazol-4-yl)-N-[4-[2-[[(2R)-2-oxidanyl-2-phenyl-ethyl]amino]ethyl]phenyl]ethanamide, Beta-3 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Shihoya, W, Yamashita, K, Nureki, O. Deposit date: 2020-11-12 Release date: 2021-08-04 Last modified: 2024-10-30 Method: ELECTRON MICROSCOPY (3.16 Å) Cite: Cryo-EM structure of the beta 3-adrenergic receptor reveals the molecular basis of subtype selectivity. Mol.Cell, 81, 2021

结合米拉贝隆（mirabegron）并与miniGs异源三聚体形成复合物的犬β3肾上腺素能受体（beta3 adrenergic receptor）。描述信息：该复合物的配体为2-(2-氨基-1,3-噻唑-4-基)-N-[4-[2-[[(2R)-2-羟基-2-苯基乙基]氨基]乙基]苯基]乙酰胺，涉及组分包括β3肾上腺素能受体、鸟嘌呤核苷酸结合蛋白G(I)/G(S)/G(O)亚基γ-2（Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2）等。作者：Shihoya W、Yamashita K、Nureki O。存档日期：2020-11-12；发布日期：2021-08-04；最后修改日期：2024-10-30。实验方法：冷冻电子显微镜（分辨率3.16埃）。引用文献：《β3肾上腺素能受体的冷冻电镜结构揭示亚型选择性的分子基础》（"Cryo-EM structure of the beta 3-adrenergic receptor reveals the molecular basis of subtype selectivity"），刊载于《分子细胞》（"Mol. Cell"）2021年第81卷。