Supplementary material

Table S01. Metadata. The table provides the SRA experiment identifiers for the reference and Gulf metagenomes, including the related MG-RAST identifier, geographical location, latitude, longitude, depth, library instrument, library layout, and PubMed references.<br><br>Table S02. PDF describing the annotated enzymes in the reference. The table shows the PDF describing the behavior of each enzyme in the reference metagenomes (normal, log-normal, gamma, and Weibull distributions).<br><br>Table S03. PDF of enzymes in metabolic pathways. The table shows the PDF describing the behavior of each enzyme in the reference metagenomes for which a metabolic pathway is described.<br><br>Table S04. EZSs of enzymes found in metabolic pathways. Enzymes with an assigned EZS were classified into the corresponding KEGG BRITE classes and metabolic maps.<br><br>Table S05. Statistical properties of enzymes grouped into BRITE classes. A summary of the measures of the central tendency and quartiles is shown in the table with the enzymes grouped into the BRITE classes.<br><br>Table S06. EC equivalences. We show the enzyme names associated with ECs related to the figures in the main text.<br><br>