ACAT2
收藏Figshare2025-07-25 更新2026-04-08 收录
下载链接：
https://figshare.com/articles/dataset/ACAT2/29641151/1
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资源简介：
Phenotypic screening identified a site-specific (Y237) and regioselective SuPUR ligand of ACAT2 to reveal an unexpected metabolic dependency in cancer cells. A crystal structure of SuPUR ligand-bound ACAT2 revealed the purine group binds deep in the CoA pocket forming key interactions with catalytic residues via a water bridge to guide future structure-based ligand design.
提供机构：
Chang, Chin-Yuan; Hsu, Ku-Lung; Tsai, Hsiao-Kuei; Li, Zhihong
创建时间：
2025-07-25
