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Intramolecular Azide−Alkyne Cycloaddition for the Fast Assembly of Structurally Diverse, Tricyclic 1,2,3-Triazoles

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https://figshare.com/articles/dataset/Intramolecular_Azide_Alkyne_Cycloaddition_for_the_Fast_Assembly_of_Structurally_Diverse_Tricyclic_1_2_3_Triazoles/2944285
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资源简介:
The synthesis of novel tricyclic 1,2,3-triazoles starting from cyclic epoxides via the sequential azidolysis, propargylation and 1,3-dipolar cycloaddition is described. Derivatization by N-arylation reaction and the synthesis of enantiomerically pure compounds is also reported. Some of these compounds exhibit significant affinity for the sigma-1 receptor.
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2016-06-03
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