Retrofitted antibodies with stabilizing mutations: Herceptin scFv mutant with VH K30D and VL S52D.

Retrofitted antibodies with stabilizing mutations: Herceptin scFv mutant with VH K30D and VL S52D. Descriptor: FORMIC ACID, Human Variable Heavy Chain of Herceptin containing VH mutation K30D, Human Variable Light Chain of Herceptin containing VL mutation S52D Authors: Langley, D.B, Roome, B, Christ, D. Deposit date: 2018-06-05 Release date: 2019-06-12 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2 Å) Cite: Retrofitting antibodies with stabilizing mutations To Be Published

经稳定突变改造的抗体：携带VH K30D与VL S52D突变的赫赛汀（Herceptin）单链可变片段（scFv）突变体。描述符：甲酸（FORMIC ACID）、携带VH K30D突变的赫赛汀人源重链可变区、携带VL S52D突变的赫赛汀人源轻链可变区。作者：Langley D.B.、Roome B.、Christ D.。提交日期：2018-06-05；发布日期：2019-06-12；最后修改日期：2024-10-23。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2 Å。引用：《通过稳定突变改造抗体》（Retrofitting antibodies with stabilizing mutations），待发表。