Serological autoantibody profiling of emmetropic controls and highly myopic patiens

High myopia is a leading cause of blindness worldwide, among which pathologic myopia, characterized by typical myopic macular degeneration, is the most detrimental. However, its pathogenesis remains largely unknown. By using a protein microarray assaying more than 20,000 human proteins, we determined in this study the autoantibody profiles of highly myopic patiens and emmetropic controls. 36 serum samples were included, 10 from emmetropic controls and 26 from highly myopic patiens. These are dual channel arrays analyzed with each channel analyzed separately.