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Assessing concordance of drug-induced transcriptional response in rodent liver and cultured hepatocytes

ChEBI2015-11-12 更新2026-07-12 收录

药物肝毒性

疾病模型转录组学

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-74903 数据链接链接失效反馈

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资源简介：

Assessing concordance of drug-induced transcriptional response in rodent liver and cultured hepatocytes

应用场景：

创建时间：

2015-11-12

药物肝毒性

斑马鱼毒理模型

Zebrafish larvae treated with triptolide (5 dpf larvae after exposure to triptolide (1.6μM) for 6 hours) or vehicle control. A total of 16 sequencing experiments were performed (control N=8 and treatm

NIAID Data Ecosystem60

Single-cell RNA sequencing analysis of iPSC-derived motor neurons from an ALS patient carrying ATXN2 intermediate repeat expansions and a healthy control

疾病模型转录组学

单细胞RNA测序

Intermediate-length repeat expansions in ATAXIN-2 (ATXN2) are a strong genetic risk factor for amyotrophic lateral sclerosis (ALS). At the molecular level, ATXN2 intermediate expansions enhance TDP-43

NIAID Data Ecosystem50

Transcriptional changes in mouse models in SCA3. Transcriptional changes in mouse models in SCA3

神经退行性机制

疾病模型转录组学

The study examined early transcriptional changes in the brain of different mouse models of spinocerebellar ataxia type 3, a dominantly-inherited neurodegenerative disease caused by a CAG repeat expans

NIAID Data Ecosystem30

Effects of Methotrexate (MTX) and Sitagliptin (Sita) on oxidative stress markers in the liver.

药物肝毒性

氧化应激标志物

Effects of Methotrexate (MTX) and Sitagliptin (Sita) on oxidative stress markers in the liver.

NIAID Data Ecosystem60

Gene expression data from primary human hepatocytes treated with GGF2 for 6, 24, or 72 h or 24 h with a 48 h washout.

药物肝毒性

基因表达谱分析

GGF2 is a recombinant human neuregulin-1β in development for chronic heart failure. Phase 1 clinical trials of GGF2 were put on hold when transient elevations in serum aminotransferases and total bili

NIAID Data Ecosystem40

Assessing concordance of drug-induced transcriptional response in rodent liver and cultured hepatocytes

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