Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their pro-drugs as antimalarial agents

Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their pro-drugs as antimalarial agents Descriptor: (2-{[2-(6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl](2-{[(E)-2-phosphonoethenyl]oxy}ethyl)amino}ethyl)phosphonic acid, Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION Authors: Keough, D.T, Hockova, D, Janeba, Z, Wang, T.-H, Naesens, L, Edstein, M.D, Chavchich, M, Guddat, L.W. Deposit date: 2014-09-10 Release date: 2015-01-07 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.871 Å) Cite: Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax 6-Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents. J.Med.Chem., 58, 2015

本数据集涵盖含第二个膦酸基团的氮杂无环核苷膦酸酯类化合物，作为人、恶性疟原虫（Plasmodium falciparum）与间日疟原虫（Plasmodium vivax）6-氧嘌呤磷酸核糖转移酶的抑制剂，及其作为抗疟剂的前体药物。
描述符：(2-{[2-(6-氧代-1,6-二氢-9H-嘌呤-9-基)乙基](2-{[(E)-2-膦酰基乙烯基]氧基}乙基)氨基}乙基)膦酸、次黄嘌呤-鸟嘌呤磷酸核糖转移酶、镁离子。
作者：Keough, D.T.、Hockova, D.、Janeba, Z.、Wang, T.-H.、Naesens, L.、Edstein, M.D.、Chavchich, M.、Guddat, L.W.
沉积日期：2014-09-10
发布日期：2015-01-07
最后修改日期：2024-02-28
测试方法：X射线衍射（1.871埃）
引用文献：《含第二个膦酸基团的氮杂无环核苷膦酸酯类化合物作为人、恶性疟原虫与间日疟原虫6-氧嘌呤磷酸核糖转移酶抑制剂及其前体抗疟剂》，《药物化学杂志》（J.Med.Chem.），第58卷，2015年