Crystal Structure of Human WRN helicase with compound 4

Crystal Structure of Human WRN helicase with compound 4 Descriptor: 1,2-ETHANEDIOL, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, CHLORIDE ION, ... Authors: Toms, A.V, Caravella, J.A, Sitnikov, N, Bartels, F, Svensson, R, Jacques O'Hagan, S, Borthwick, J, Yin, Y, Zhoa, X, Li, L, Liu, R, Talbot, E, Kong, H, Freund, R.R.A, Browning, B, Genung, N, Carreiro, S, Brennan, D, Graves, A.P, Loh, C, Tummino, P, Edmondson, S.D, Li, D. Deposit date: 2026-01-08 Release date: 2026-05-13 Last modified: 2026-06-10 Method: X-RAY DIFFRACTION (1.37 Å) Cite: Design of Cyclic Vinyl Sulfones as WRN Covalent Inhibitors from Noncovalent Binders. J.Med.Chem., 69, 2026