Table 1_Risk of mental health conditions in bereavement: a population-based analysis of lung cancer spouses.docx

BackgroundCaregiving to lung cancer patients is distressing, isolating, and associated with a high burden of anxiety and depression. However, few population-based studies in the U.S. have examined the risk of mental health conditions (MHCs) among spouses of lung cancer patients after the death of their partner. Guided by Anderson’s Behavioral Health Utilization model, we examined the role of sex, pre-bereavement MHC, and decedents’ healthcare utilization on the risk of having a diagnosed MHC after the death of a lung cancer patient.
MethodsThis retrospective cohort study linked state-wide health facility records of 1,224 dyads—deceased lung cancer patients and their bereaved spouses (824 female, 400 male)—in Utah between 2013 and 2021. Bereavement-related mood/stress-related conditions were identified for spouses using diagnostic codes (starting from day 1 following the patients’ deaths). The Kaplan–Meier curves and Cox proportional hazard models were used to estimate the risk for a composite outcome of MHC/death and the risk of MHC, after adjusting for censorship due to death and controlling for covariates.
ResultsThe majority of spouses were aged 65+ (female: 67%; male: 33%), white/non-Hispanic (female: 89%; male: 90%), and urban-dwelling (female: 69%; male: 71%). Spouses experienced 374 events (MHCs/death) across the follow-up period. Adjusting for census-tract level income, cancer stage, insurance, censoring due to death, and the interaction between sex and MHC, spouses with preexisting MHCs had 4.09 times higher risk of developing MHCs during bereavement (95% CI: 2.70, 6.19) compared to spouses without pre-existing MHCs. Spouses of decedents with some college education (aHR: 0.68, 95% CI = 0.48–0.97) and longer survival (aHR: 0.85, 95% CI = 0.74–0.99) had a lower risk of MHCs compared to those of decedents with high school education and shorter survival.
DiscussionThis population-based study supports evidence for multi-level risk factors associated with having MHC after the death of a spouse with lung cancer. Findings suggest the need for targeted bereavement support for subgroups of spouses at greater risk of MHCs.