CIL:13607, Homo sapiens, fibroblast. In Cell Image Library
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Behavior of a patient-derived human fibroblast line (PD-NC4) containing a mutated chromosome 4 in which the normal centromere is epigenetically silenced and a neo-centromere has formed 25 Mbp down the q arm at a site that lacks centromere repeats.
Shown is a z-series of a metaphse spread stained with anti-centromere antibody (ACA, green) which labels both the epigenetically silenced centromere and the neocentromere of chromosome 4 which appears in the lower left quadrant in the z-slice displayed. Also stained for DNA with DAPI (blue). See Fig 1A in Bassett et al. 2010. Epigenetic centromere specification directs aurora B accumulation but is insufficient to efficiently correct mitotic errors. J Cell Biol 190:177-185.
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UC San Diego Library Digital Collections
创建时间：
2021-04-15
