CryoEM structure of catalytic domain of human HMG-CoA reductase with its inhibitor atorvastatin

CryoEM structure of catalytic domain of human HMG-CoA reductase with its inhibitor atorvastatin Descriptor: 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 7-[2-(4-FLUORO-PHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-PYRROL-1-YL]- 3,5-DIHYDROXY-HEPTANOIC ACID Authors: Manikandan, K, Van Rooyen, J. Deposit date: 2023-06-27 Release date: 2025-01-15 Last modified: 2025-03-12 Method: ELECTRON MICROSCOPY (2.26 Å) Cite: Cryo-EM structures of apo and atorvastatin-bound human 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Acta Crystallogr.,Sect.F, 81, 2025人源HMG-CoA还原酶（HMG-CoA reductase）催化结构域与其抑制剂阿托伐他汀（atorvastatin）结合的冷冻电镜（CryoEM）结构 描述符：3-羟基-3-甲基戊二酰辅酶A还原酶（3-hydroxy-3-methylglutaryl-coenzyme A reductase），7-[2-(4-氟苯基)-5-异丙基-3-苯基-4-苯基氨基甲酰基吡咯-1-基]-3,5-二羟基庚酸 作者：Manikandan, K、Van Rooyen, J. 存入日期：2023-06-27 发布日期：2025-01-15 最后修改日期：2025-03-12 实验方法：电子显微镜法（分辨率2.26 Å） 引用文献：Manikandan, K, Van Rooyen, J. 无配体与阿托伐他汀结合的人源3-羟基-3-甲基戊二酰辅酶A还原酶的冷冻电镜结构. 《晶体学报F辑》, 81卷, 2025年