External validation of prognostic models for preeclampsia in a Dutch multicenter prospective cohort

<b>Objective</b>: To perform an external validation of all published prognostic models for first-trimester prediction of the risk of developing preeclampsia (PE). <b>Methods</b>: Women &lt;14 weeks of pregnancy were recruited in the Netherlands. All systematically identified prognostic models for PE that contained predictors commonly available were eligible for external validation. <b>Results</b>: 3,736 women were included; 87 (2.3%) developed PE. Calibration was poor due to overestimation. Discrimination of 9 models for LO-PE ranged from 0.58 to 0.71 and of 9 models for all PE from 0.55 to 0.75. <b>Conclusion</b>: Only a few easily applicable prognostic models for all PE showed discrimination above 0.70, which is considered an acceptable performance.