Frequency of substitutions that enhance repression.
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a: Each parent protein was counted as one of the amino acids in all 12 positions.b: % substitutions enhancing = (enhanced >10-fold)/(Total variants – Parent proteins mutated).c: All enhancing substitutions at positions 46 and 48 occurred in “LXhX” chimeras, which had domain fusion between the DNA binding domain and linker.
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2015-12-02
