Intervention with Micronutrients and Long-Term Impact in Brazil-RECODISA

Intervention with Micronutrients and Long-Term Impact in Brazil, a partnership between the Federal University of Ceará, Brazil and the University of Virginia, USA, enrolled infants in the age group of 2-36 months to investigate trends in gastrointestinal infections and their effects on growth and development and to identify genetic factors contributing to these diseases.A total of 1044 children from six urban communities in Brazil's semiarid region, were enrolled during active surveillance; those with diarrhea (three or more liquid stools in the last 24 hours at enrollment) were defined as a cases and matched with controls having no diarrhea during the past two weeks (at enrollment) to evaluate their growth and development. A subset of 664 children with their genetic and associated phenotypic data is included in this submission. More information on this project and its related projects can be found here: Studies of diarrheal susceptibility, growth, and development, in pediatric populations in Northeastern Brazil]]>
Inclusion criteria (Cases): - Had three or more liquid stools in the last 24 hours - Had no chronic illness or hospitalization with 12 hours of study enrollment - Written consent provided by parents or legal guardians Inclusion criteria (Controls): - Did not present with diarrhea in the past 2 weeks - Written consent provided by parents or legal guardians ]]>
Enrollment in this study occurred between 2010 and 2014. The children were evaluated to measure anthropometry and feeding practices and stool samples collected for molecular diagnostics for enteropathogens and inflammatory biomarkers. ]]>